Article

Small molecule G-quadruplex ligands are antibacterial candidates for Gram-negative bacteria

2022-09-02

Abstract excerpt

<h4>ABSTRACT</h4> There is great need for novel strategies to tackle antimicrobial resistance, in particular in Gram-negative species such as Escherichia coli that cause opportunistic infections of already compromised patients. Here we demonstrate, following a screen of G-quadruplex (G4) ligand candidates, that a novel pyridinium-functionalized azobenzene L9 shows promising antibacterial activity (MIC values ≤...

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Literature Corpus work: 464db293-c464-52c0-aa8c-364d6db02a33
DOI: 10.1101/2022.09.01.506212

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