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Aurodox, a polyketide from <i>Streptomyces goldiniensis</i> , inhibits transcription of the type III secretion system of multiple Gram-negative pathogens

2024-04-19

Abstract excerpt

Gram-negative pathogens pose a significant threat due to their propensity for causing various infections, often coupled with formidable resistance to conventional antibiotic treatments. In light of this challenge, the development of antivirulence (AV) compounds emerges as a promising alternative strategy, aiming to disrupt key virulence mechanisms rather than directly targeting bacterial viability. One such compou...

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Literature Corpus work
681557c5-98a9-5218-86a4-8c4abd2156a6
DOI
10.1101/2024.04.19.589875
Open publication

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Aurodox, a polyketide from <i>Streptomyces goldiniensis</i> , inhibits transcription of the type III secretion system of multiple Gram-negative pathogensDOI 10.1101/2024.04.19.589875
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