Back to search

Article

Molecular response to the non-lytic peptide bac7 (1-35) triggers disruption of <i>Klebsiella pneumoniae</i> biofilm

2025-08-11

Abstract excerpt

Klebsiella pneumoniae is becoming increasingly difficult to treat as multidrug-resistant (MDR) strains become more prevalent. The formation of biofilm heightens this threat by embedding bacterial cells in a polysaccharide-rich matrix that limits antibiotic penetration. Here we dissect the anti-biofilm bovine host-defense cathelicidin peptide fragment bac7 (1-35), exploring its anti-biofilm mechanism, evaluating it...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9abb01c1-e772-580d-bce5-2834a806860c
DOI
10.1101/2025.08.08.669280
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Molecular response to the non-lytic peptide bac7 (1-35) triggers disruption of <i>Klebsiella pneumoniae</i> biofilmDOI 10.1101/2025.08.08.669280
The Antimicrobial Peptide CRAMP-34 Eradicates <em>Escherichia coli</em> Biofilms by Interfering with the <em>kduD</em>-Dependent NetworkSemantic proximity
Harnessing Lytic Phages for Biofilm Control in Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Causing Urinary Tract InfectionSemantic proximity
Caerin 1.1/1.9 disrupts growth and biofilms of carbapenem-resistant Klebsiella pneumoniae with a transcriptomic signature of translational and metabolic stressSemantic proximity
Outer Membrane Vesicles derived from Klebsiella pneumoniae enhance biofilm formation and matrix integrity by delivering biofilm-associated mRNAsSemantic proximity
Deciphering the dynamics of methicillin-resistant Staphylococcus aureus biofilm formation: from molecular signaling to nanotherapeutic advancesSemantic proximity
Universal-Bac <sup>3</sup> Gel <sup>®</sup> : a 3D Biofilm-Relevant Matrix that Supports <i>In Vitro</i> Growth and Biofilm Formation of ESKAPE PathogensSemantic proximity
Analysis of a New Phage, KZag1, Infecting Biofilm of Klebsiella pneumoniae: Genome Sequence and CharacterizationSemantic proximity
Tryptophan-substitution antimicrobial peptide temporin-1CEb: in vitro and in vivo antibacterial activity against clinically isolated multidrug-resistant <i>Klebsiella pneumoniae</i>Semantic proximity
Repurposing host-guest chemistry to sequester virulence and eradicate biofilms in multidrug resistant <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i>Semantic proximity
Selective inhibition of the amyloid matrix of <i>Escherichia coli</i> biofilms by a bifunctional microbial metaboliteSemantic proximity
Anti-biofilm activity of antimicrobial peptide CRAMP-34 by regulating 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (KduD) of Escherichia coliSemantic proximity
Next-Generation Antimicrobial Peptide for Biofilm-Associated Infections: Engineering, Biomaterial Delivery and AI-Assisted DiscoverySemantic proximity
Select a neighboring publication to make it the new centre.