Article

Nanoliter-scale selection of optimized bioengineered peptide antibiotics that rescue mice with bacterial lung infection

2024-06-01

Abstract excerpt

Increasing numbers of multi-drug resistant pathogens call for new chemical scaffolds, addressing novel targets, that can serve as lead structures for the development of life-saving drugs. For antibiotics, natural product-inspired molecules represent a most promising resource. Natural products evolved to high chemical complexity and occupy a chemical space different than synthetic libraries. However, clinical trans...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 117b32dd-64f3-55a4-b4b1-0b7ce3458ef9
DOI: 10.1101/2024.05.30.596569

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nanoliter-scale selection of optimized bioengineered peptide antibiotics that rescue mice with bacterial lung infectionDOI 10.1101/2024.05.30.596569Read

New Genetically Engineered Derivatives of Antibacterial Darobactins Underpin Their Potential for Antibiotic DevelopmentSemantic proximity Read

Antibiotic Discovery with Synthetic Fermentation: Library Assembly, Phenotypic Screening, and Mechanism of Action of Beta-Peptides Targeting Penicillin-Binding ProteinsSemantic proximity Read

Next-Generation Antimicrobial Peptide for Biofilm-Associated Infections: Engineering, Biomaterial Delivery and AI-Assisted DiscoverySemantic proximity Read

The Anti- <i>Burkholderia</i> Lasso Peptide Ubonodin Co-Opts the Siderophore Receptor PupB for Cellular EntrySemantic proximity Read

Discovery of antibiotics in the archaeome using deep learningSemantic proximity Read

Microbial natural products: molecular blueprints for antitumor drugsSemantic proximity Read

Frontiers in Antimicrobial Drug Discovery: Current Approaches and InnovationsSemantic proximity Read

Reporter-Based Assays for High-Throughput Drug Screening against Mycobacterium abscessusSemantic proximity Read

Chimeric peptidomimetic antibiotics against Gram-negative bacteria.Semantic proximity Read

Peptides for Infectious Diseases: From Probe Design to Diagnostic MicroarraysSemantic proximity Read

Innovative Strategies and Methodologies in Antimicrobial Peptide DesignSemantic proximity Read

Screening Privileged Alkyl Guanidinium Motifs under Host-Mimicking Conditions Reveals a Novel Antibiotic with an Unconventional Mode of ActionSemantic proximity Read