Article

Adapting antibacterial display to identify serum active macrocyclic peptide antibiotics

2023-07-28

Abstract excerpt

The lack of available treatments for many antimicrobial resistant infections highlights the critical need for antibiotic discovery innovation. Peptides are an underappreciated antibiotic scaffold because they often suffer from proteolytic instability and toxicity towards human cells, making in vivo use challenging. To investigate sequence factors related to serum activity, we adapt an antibacterial display techno...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b66eb4bf-fe5c-5a46-95b3-7a587d73f84b
DOI: 10.1101/2023.07.28.550711

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Adapting antibacterial display to identify serum active macrocyclic peptide antibioticsDOI 10.1101/2023.07.28.550711Read

Phage Display of Dynamic Covalent Binding Motifs Enables Facile Development of Targeted AntibioticsSemantic proximity Read

Synthetic molecular evolution of host cell-compatible, antimicrobial peptides effective against drug-resistant, biofilm-forming bacteriaSemantic proximity Read

Next-Generation Antimicrobial Peptide for Biofilm-Associated Infections: Engineering, Biomaterial Delivery and AI-Assisted DiscoverySemantic proximity Read

Polycyclic Peptide TherapeuticsSemantic proximity Read

Development of Anti-Infectives Using Phage Display: Biological Agents against Bacteria, Viruses, and ParasitesSemantic proximity Read

Optimization of host cell-compatible, antimicrobial peptides effective against biofilms and clinical isolates of drug-resistant bacteriaSemantic proximity Read

Targeted Modification of the Antimicrobial Peptide DGL13K Reveals a Naturally Optimized Sequence for Topical ApplicationsSemantic proximity Read

Nonribosomal antibacterial peptides that target multidrug-resistant bacteriaSemantic proximity Read

Chimeric peptidomimetic antibiotics against Gram-negative bacteria.Semantic proximity Read

Screening Privileged Alkyl Guanidinium Motifs under Host-Mimicking Conditions Reveals a Novel Antibiotic with an Unconventional Mode of ActionSemantic proximity Read

Nanoliter-scale selection of optimized bioengineered peptide antibiotics that rescue mice with bacterial lung infectionSemantic proximity Read

Innovative Strategies and Methodologies in Antimicrobial Peptide DesignSemantic proximity Read