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New Genetically Engineered Derivatives of Antibacterial Darobactins Underpin Their Potential for Antibiotic Development

21 Nov 2023

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Biosynthetic engineering of bicyclic darobactins, selectively sealing the lateral gate of the outer membrane protein BamA, leads to active analogues, which are up to 128-fold more potent against Gram-negative pathogens compared to native counterparts. Because of their excellent antibacterial activity, darobactins represent one of the most promising new antibiotic...

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PMID: 38093695
DOI: 10.1021/acs.jmedchem.3c01660

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