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Article

Irc20 modulates LOH frequency and distribution in S. cerevisiae.

DNA repair - 1 Sept 2024

Joshi Sameer, Dash Suman, Vijayan Nikilesh, Nishant Koodali T

Abstract excerpt

Loss of Heterozygosity (LOH) due to mitotic recombination is frequently associated with the development of various cancers (e.g. retinoblastoma). LOH is also an important source of genetic diversity, especially in organisms where meiosis is infrequent. Irc20 is a putative helicase, and E3 ubiquitin ligase involved in DNA double-strand break repair pathway. We analyzed genome-wide LOH events, gross chromosomal...

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Identifiers

PMID: 39098164
DOI: 10.1016/j.dnarep.2024.103727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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