Article

Germline Missense Variants in <i>CDC20</i> Result in Aberrant Mitotic Progression and Familial Cancer

2021-09-14

Abstract excerpt

<h4>SUMMARY</h4> CDC20 is a co-activator of the anaphase promoting complex/cyclosome (APC/C) and is essential for mitotic progression. APC/C CDC20 is inhibited by the spindle assembly checkpoint (SAC), which prevents premature separation of sister chromatids and aneuploidy in daughter cells. Although overexpression of CDC20 is common in many cancers, oncogenic mutations have never been identified in humans. Usi...

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Literature Corpus work: dbf046c2-6067-59b9-ab12-799c083be40b
DOI: 10.1101/2021.09.13.459529

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