Article

Interstitial telomeric sequences promote gross chromosomal rearrangement via multiple mechanisms

2024-04-13

Abstract excerpt

Telomeric DNA sequences are difficult to replicate. Replication forks frequently pause or stall at telomeres, which can lead to telomere truncation and dysfunction. In addition to being at chromosome ends, telomere repeats are also present at internal locations within chromosomes, known as interstitial telomeric sequences (ITSs). These sequences are unstable and prone to triggering gross chromosomal rearrangements...

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Literature Corpus work: 294d7d18-7f8f-508b-9359-e8e9abcb9666
DOI: 10.1101/2024.04.11.589032

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