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Article

Genome-wide mapping of spontaneous genetic alterations in diploid yeast cells.

Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 2020

Sui Yang, Qi Lei, Wu Jian-Kun, Wen Xue-Ping, Tang Xing-Xing, Ma Zhong-Jun, Wu Xue-Chang, Zhang Ke, Kokoska Robert J, Zheng Dao-Qiong, Petes Thomas D

Abstract excerpt

Genomic alterations including single-base mutations, deletions and duplications, translocations, mitotic recombination events, and chromosome aneuploidy generate genetic diversity. We examined the rates of all of these genetic changes in a diploid strain of Saccharomyces cerevisiae by whole-genome sequencing of many independent isolates (n = 93) subcloned about 100 times in unstressed growth conditions. The most...

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Identifiers

PMID: 33106417
DOI: 10.1073/pnas.2018633117
PMCID: PMC7668089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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