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Molecular Underpinnings and Environmental Drivers of Spontaneous Loss of Heterozygosity in <i>Drosophila</i> Intestinal Stem Cells

2022-07-22

Abstract excerpt

The genome stability of adult stem cells is of particular importance as these cells maintain long-term self-renewal capacity and can contribute extensively to adult tissues. During development and aging, genome mutation leading to loss of heterozygosity (LOH) can uncover recessive phenotypes and be propagated within tissue compartments. This phenomenon occurs in normal human tissues, and is prevalent in pathologic...

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Literature Corpus work
3ce34e28-ac33-58d8-8541-4cbf45ce64db
DOI
10.1101/2022.07.21.500951
Open publication

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Molecular Underpinnings and Environmental Drivers of Spontaneous Loss of Heterozygosity in <i>Drosophila</i> Intestinal Stem CellsDOI 10.1101/2022.07.21.500951
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