A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae.

doi:10.1534/genetics.108.089250

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae.

Genetics - 1 Jul 2008

Andersen Marguerite P, Nelson Zara W, Hetrick Elizabeth D, Gottschling Daniel E

Abstract excerpt

Loss of heterozygosity (LOH) can be a driving force in the evolution of mitotic/somatic diploid cells, and cellular changes that increase the rate of LOH have been proposed to facilitate this process. In the yeast Saccharomyces cerevisiae, spontaneous LOH occurs by a number of mechanisms including chromosome loss and reciprocal and nonreciprocal recombination. We performed a screen in diploid yeast to identify...

Topics

Alleles
Chromatin Assembly and Disassembly
Chromosomes, Fungal
Cysteine Synthase
DNA Breaks, Double-Stranded
DNA Replication
Gene Deletion
Genes, Fungal
Genetic Markers
Genomic Instability
Loss of Heterozygosity
Multienzyme Complexes
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18562670
DOI: 10.1534/genetics.108.089250
PMCID: PMC2475725

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics