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Article

High-resolution genome-wide analysis of irradiated (UV and γ-rays) diploid yeast cells reveals a high frequency of genomic loss of heterozygosity (LOH) events.

Genetics - 1 Apr 2012

St Charles Jordan, Hazkani-Covo Einat, Yin Yi, Andersen Sabrina L, Dietrich Fred S, Greenwell Patricia W, Malc Ewa, Mieczkowski Piotr, Petes Thomas D

Abstract excerpt

In diploid eukaryotes, repair of double-stranded DNA breaks by homologous recombination often leads to loss of heterozygosity (LOH). Most previous studies of mitotic recombination in Saccharomyces cerevisiae have focused on a single chromosome or a single region of one chromosome at which LOH events can be selected. In this study, we used two techniques (single-nucleotide polymorphism microarrays and...

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Identifiers

PMID: 22267500
DOI: 10.1534/genetics.111.137927
PMCID: PMC3316642

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Source receipt: pubmed, retrieved 7 Sept 2026.

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