Article
Characterization of systemic genomic instability in budding yeast.
Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 2020
Sampaio Nadia M V, Ajith V P, Watson Ruth A, Heasley Lydia R, Chakraborty Parijat, Rodrigues-Prause Aline, Malc Ewa P, Mieczkowski Piotr A, Nishant Koodali T, Argueso Juan Lucas
Abstract excerpt
Conventional models of genome evolution are centered around the principle that mutations form independently of each other and build up slowly over time. We characterized the occurrence of bursts of genome-wide loss-of-heterozygosity (LOH) in Saccharomyces cerevisiae, providing support for an additional nonindependent and faster mode of mutation accumulation. We initially characterized a yeast clone isolated for...
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