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Article

The dynamics of loss of heterozygosity events in genomes.

EMBO reports - 1 Feb 2025

Dutta Abhishek, Schacherer Joseph

Abstract excerpt

Genomic instability is a hallmark of tumorigenesis, yet it also plays an essential role in evolution. Large-scale population genomics studies have highlighted the importance of loss of heterozygosity (LOH) events, which have long been overlooked in the context of genetic diversity and instability. Among various types of genomic mutations, LOH events are the most common and affect a larger portion of the genome....

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Identifiers

PMID: 39747660
DOI: 10.1038/s44319-024-00353-w
PMCID: PMC11811284

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