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Article

Folate intake and colorectal cancer risk according to genetic subtypes defined by targeted tumor sequencing.

The American journal of clinical nutrition - 1 Sept 2024

Aglago Elom K, Qu Conghui, Harlid Sophia, Phipps Amanda I, Steinfelder Robert S, Ogino Shuji, Thomas Claire E, Hsu Li, Toland Amanda E, Brenner Hermann, Berndt Sonja I, Buchanan Daniel D, Campbell Peter T, Cao Yin, Chan Andrew T, Drew David A, Figueiredo Jane C, French Amy J, Gallinger Steven, Georgeson Peter, Giannakis Marios, Goode Ellen L, Gruber Stephen B, Gunter Marc J, Harrison Tabitha A, Hoffmeister Michael, Huang Wen-Yi, Hullar Meredith Aj, Huyghe Jeroen R, Jenkins Mark A, Lynch Brigid M, Moreno Victor, Murphy Neil, Newton Christina C, Nowak Jonathan A, Obón-Santacana Mireia, Sun Wei, Ugai Tomotaka, Um Caroline Y, Zaidi Syed H, Tsilidis Konstantinos K, van Guelpen Bethany, Peters Ulrike

Abstract excerpt

BACKGROUND: Folate is involved in multiple genetic, epigenetic, and metabolic processes, and inadequate folate intake has been associated with an increased risk of cancer. OBJECTIVE: We examined whether folate intake is differentially associated with colorectal cancer (CRC) risk according to somatic mutations in genes linked to CRC using targeted sequencing. DESIGN: Participants within 2 large CRC consortia with...

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Identifiers

PMID: 39025327
DOI: 10.1016/j.ajcnut.2024.07.012
PMCID: PMC11393398

Genes

CHD1
DOCK3
ZNF521
ATM
AXIN2
B2M
BCOR
FBLN2
IGF2
MAP3K21
POLD1
RYR1
TET2
TP53
UTP20

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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