Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Folate metabolism-associated CYP26A1 is a clinico-immune target in colorectal cancer

2 Jul 2025

Abstract excerpt

Folic acid plays a crucial role in cellular regulation and metabolism, commonly included in dietary supplements. Despite this, its involvement in colorectal cancer (CRC), particularly in metabolic pathways and immune evasion, remains poorly understood. We developed the FMRG_score system using machine learning algorithms on TCGA and GEO data to assess modification patterns influencing clinical outcomes and immune...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Ferroptosis and cancer prognosis
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40604317
DOI: 10.1038/s41435-025-00342-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Folate metabolism-associated CYP26A1 is a clinico-immune target in colorectal cancerPMID 40604317Read ↗

Folate Metabolism in Colorectal Cancer Reveals Links Between Clinical and Immune Traits, Identifying CYP26A1 as a TargetSemantic proximity Read ↗

A Novel Prognostic Model for Colon Adenocarcinoma Based on Cofactor and Vitamin Metabolism-Related GenesSemantic proximity Read ↗

MTHFD1L, A Folate Cycle Enzyme, Is Involved in Progression of Colorectal CancerSemantic proximity Read ↗

Constructing a novel mitochondrial metabolism-related genes signature to evaluate tumor immune microenvironment and predict survival of colorectal cancerSemantic proximity Read ↗

Folate intake and colorectal cancer risk according to genetic subtypes defined by targeted tumor sequencing.Semantic proximity Read ↗

Ferroptosis-disulfidptosis-related CHMP6 is a clinico-immune target in colorectal cancerSemantic proximity Read ↗

Gut microbiome derived folate metabolite suppresses colorectal cancer progressionSemantic proximity Read ↗

Amino acid metabolism genes associated with immunotherapy responses and clinical prognosis of colorectal cancerSemantic proximity Read ↗

How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy.Semantic proximity Read ↗

Association between immune cell attributes, serum metabolites, inflammatory protein factors, and colorectal cancer: A Mendelian randomization study.Semantic proximity Read ↗

Epigenomic effects of vitamin D in colorectal cancerSemantic proximity Read ↗

SNPs and blood inflammatory marker featured machine learning for predicting the efficacy of fluorouracil-based chemotherapy in colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.