Article

Mutagenicity of folic acid deficiency and supplementation is tissue-specific and results in distinct mutation profiles

2020-07-29

Abstract excerpt

Cancer incidence varies by tissue due to differences in environmental risk factor exposure, gene variant inheritance, and lifetime number of stem cell divisions in a tissue. Folate deficiency is associated with increased risk for colorectal cancer (CRC) and acute lymphocytic leukemia. Conversely, high folic acid (FA) intake has been associated with higher CRC risk. However, the mutagenic potential of FA intake in...

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Literature Corpus work: f66e3ef3-f86b-5bc7-a764-cf16577cb02b
DOI: 10.1101/2020.07.27.223552

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