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Article

How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy.

Cancer letters - 28 Jan 2015

Jennings Barbara Anne, Willis Gavin

Abstract excerpt

Folate was identified as an essential micronutrient early in the twentieth century and anti-folate chemotherapy such as 5-fluorouracil (5-FU) has been central to the medical management of solid tumours including colorectal cancer for more than five decades. In the intervening years, evidence has been gathered which shows that folate deficiency leads to many human diseases throughout the life-course. However, we...

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Source

Identifiers

PMID: 24614284
DOI: 10.1016/j.canlet.2014.02.024

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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