Article

Folate Metabolism in Colorectal Cancer Reveals Links Between Clinical and Immune Traits, Identifying CYP26A1 as a Target

2025-01-28

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold>Folic acid plays a key role in cellular regulation and metabolism, commonly found in dietary supplements. However, its complex role in colorectal cancer (CRC), particularly in metabolism and immune evasion, remains unclear. <bold>Methods:</bold>We developed the FMRG_score system using machine learning algorithms based on TCGA and GEO databases to assess modificat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7b930659-9312-5242-bbfe-b1747a9136f9
DOI: 10.21203/rs.3.rs-5647525/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Folate Metabolism in Colorectal Cancer Reveals Links Between Clinical and Immune Traits, Identifying CYP26A1 as a TargetDOI 10.21203/rs.3.rs-5647525/v1Read

Folate metabolism-associated CYP26A1 is a clinico-immune target in colorectal cancerSemantic proximity Read

A Novel Prognostic Model for Colon Adenocarcinoma Based on Cofactor and Vitamin Metabolism-Related GenesSemantic proximity Read

MTHFD1L, A Folate Cycle Enzyme, Is Involved in Progression of Colorectal CancerSemantic proximity Read

How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy.Semantic proximity Read

Epigenomic effects of vitamin D in colorectal cancerSemantic proximity Read

Folate intake and colorectal cancer risk according to genetic subtypes defined by targeted tumor sequencing.Semantic proximity Read

FTO promotes colorectal cancer progression and chemotherapy resistance via demethylating G6PD/PARP1Semantic proximity Read

Polymorphisms of folate metabolism-related genes and survival of patients with colorectal cancer in the Korean populationSemantic proximity Read

Gut microbiome derived folate metabolite suppresses colorectal cancer progressionSemantic proximity Read

Pharmacogenomics of 5-fluorouracil in colorectal cancer: review and updateSemantic proximity Read

Glutathione Reductase change the tumor immune microenvironment and prognosis of colon cancer：A study based on proteomic analysisSemantic proximity Read

SNPs and blood inflammatory marker featured machine learning for predicting the efficacy of fluorouracil-based chemotherapy in colorectal cancer.Semantic proximity Read