Article
Plasma folate, related genetic variants, and colorectal cancer risk in EPIC.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2010
Eussen Simone J P M, Vollset Stein Emil, Igland Jannicke, Meyer Klaus, Fredriksen Ase, Ueland Per Magne, Jenab Mazda, Slimani Nadia, Boffetta Paolo, Overvad Kim, Tjønneland Anne, Olsen Anja, Clavel-Chapelon Françoise, Boutron-Ruault Marie-Christine, Morois Sophie, Weikert Cornelia, Pischon Tobias, Linseisen Jakob, Kaaks Rudolf, Trichopoulou Antonia, Zilis Demosthenes, Katsoulis Michael, Palli Domenico, Berrino Franco, Vineis Paolo, Tumino Rosario, Panico Salvatore, Peeters Petra H M, Bueno-de-Mesquita H Bas, van Duijnhoven Fränzel J B, Gram Inger Torhild, Skeie Guri, Lund Eiliv, González Carlos A, Martínez Carmen, Dorronsoro Miren, Ardanaz Eva, Navarro Carmen, Rodríguez Laudina, Van Guelpen Bethany, Palmqvist Richard, Manjer Jonas, Ericson Ulrika, Bingham Sheila, Khaw Kay-Tee, Norat Teresa, Riboli Elio
Abstract excerpt
BACKGROUND: A potential dual role of folate in colorectal cancer (CRC) is currently subject to debate. We investigate the associations between plasma folate, several relevant folate-related polymorphisms, and CRC risk within the large European Prospective Investigation into Cancer and Nutrition cohort. METHODS: In this nested case-control study, 1,367 incident CRC cases were matched to 2,325 controls for study...
Read the complete abstract on PubMed