A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk.

doi:10.1158/1055-9965.EPI-10-0151

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Article

A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2010

Levine A Joan, Figueiredo Jane C, Lee Won, Conti David V, Kennedy Kathleen, Duggan David J, Poynter Jenny N, Campbell Peter T, Newcomb Polly, Martinez Maria Elena, Hopper John L, Le Marchand Loic, Baron John A, Limburg Paul J, Ulrich Cornelia M, Haile Robert W

Abstract excerpt

BACKGROUND: Folate-associated one-carbon metabolism (FOCM) may play an important role in colorectal carcinogenesis. Variation in FOCM genes may explain some of the underlying risk of colorectal cancer. METHODS: This study utilized data from 1,805 population-based colorectal cancer cases and 2,878 matched sibling controls from the Colon Cancer Family Registry. We used a comprehensive haplotype tagging single...

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PMID: 20615890
DOI: 10.1158/1055-9965.EPI-10-0151
PMCID: PMC2950115

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DHFR
IMPACT
MTR

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