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Article

Folate-genetics and colorectal neoplasia: what we know and need to know next.

Molecular nutrition & food research - 1 Apr 2013

Figueiredo Jane C, Levine A Joan, Crott Jimmy W, Baurley James, Haile Robert W

Abstract excerpt

SCOPE: The metabolism of folate involves a complex network of polymorphic enzymes that may explain a proportion of the risk associated with colorectal neoplasia. Over 60 observational studies primarily in non-Hispanic White populations have been conducted on selected genetic variants in specific genes, MTHFR, MTR, MTRR, CBS, TCNII, RFC, GCPII, SHMT, TYMS, and MTHFD1, including five meta-analyses on MTHFR 677C>T...

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Source

Identifiers

PMID: 23401104
DOI: 10.1002/mnfr.201200278

Genes

MTHFR
MTR
MTRR
TYMS
CBS
MTHFD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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