The association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia.

doi:10.3945/ajcn.113.061432

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia.

The American journal of clinical nutrition - 1 Dec 2013

Hanks Joanna, Ayed Iyeman, Kukreja Neil, Rogers Chris, Harris Jessica, Gheorghiu Alina, Liu Chee Ling, Emery Peter, Pufulete Maria

Abstract excerpt

BACKGROUND: Decreased genomic and increased gene-specific DNA methylation predispose to colorectal cancer. Dietary folate intake and the methylenetetrahydrofolate reductase polymorphism (MTHFR 677C>T) may influence risk by modifying DNA methylation. OBJECTIVE: We investigated the associations between MTHFR 677C>T genotype, folate status, and DNA methylation in the colon. DESIGN: We conducted a cross-sectional...

Topics

Adult
Aged
Aged, 80 and over
Biomarkers
Colon
Colorectal Neoplasms
Cross-Sectional Studies
DNA Methylation
Diet
Folic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Folic Acid Deficiency

Genetic Association Studies

Humans

Intestinal Mucosa

Methylenetetrahydrofolate Reductase (NADPH2)

Middle Aged

Nutritional Status

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 24108782
DOI: 10.3945/ajcn.113.061432
PMCID: PMC3831541

Genes

MTHFR
MGMT
APC
ESR1
IGF2
MLH1
MYOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24108782-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia.PMID 24108782Read ↗

Influence of folate status on genomic DNA methylation in colonic mucosa of subjects without colorectal adenoma or cancer.Semantic proximity Read ↗

Folate-genetics and colorectal neoplasia: what we know and need to know next.Semantic proximity Read ↗

Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer.Semantic proximity Read ↗

Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study.Semantic proximity Read ↗

Plasma folate, related genetic variants, and colorectal cancer risk in EPIC.Semantic proximity Read ↗

Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake.Semantic proximity Read ↗

MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer.Semantic proximity Read ↗

Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer.Semantic proximity Read ↗

Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review.Semantic proximity Read ↗

Localized depletion: the key to colorectal cancer risk mediated by MTHFR genotype and folate?Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.Semantic proximity Read ↗

Folate intake and colorectal cancer risk according to genetic subtypes defined by targeted tumor sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.