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Article

Current State and Future of Polygenic Risk Scores in Cardiometabolic Disease: A Scoping Review.

Circulation. Genomic and precision medicine - 1 Jun 2023

Phulka Jobanjit S, Ashraf Mishal, Bajwa Beenu K, Pare Guillaume, Laksman Zachary

Abstract excerpt

A polygenic risk score (PRS) is derived from a genome-wide association study and represents an aggregate of thousands of single-nucleotide polymorphisms that provide a baseline estimate of an individual's genetic risk for a specific disease or trait at birth. However, it remains unclear how PRSs can be used in clinical practice. We provide an overview of the PRSs related to cardiometabolic disease and discuss the...

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PMID: 37035923
DOI: 10.1161/CIRCGEN.122.003834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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