Article

Use of polygenic risk scores and other molecular markers to enhance cardiovascular risk prediction: prospective cohort study and modelling analysis

2019-08-22

Abstract excerpt

<h4>Background</h4> There is debate about the value of adding information on genetic and other molecular markers to conventional cardiovascular disease (CVD) risk predictors. <h4>Methods</h4> Using data on 306,654 individuals without a history of CVD from UK Biobank, we calculated measures of risk-discrimination and reclassification upon addition of polygenic risk scores (PRS) and a panel of 27 clinical biochemi...

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Literature Corpus work: 07f34032-2cb8-5afd-b351-05171140cb5f
DOI: 10.1101/744565

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