Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

From Genome-wide Association Studies to Functional Variants: ARL14 Cis-regulatory Variants Are Associated With Severe Malaria.

The Journal of infectious diseases - 23 Sept 2024

Adjemout Mathieu, Gallardo Frederic, Torres Magali, Thiam Alassane, Mbengue Babacar, Dieye Alioune, Marquet Sandrine, Rihet Pascal

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified several nonfunctional tag single-nucleotide polymorphisms (SNPs) associated with severe malaria. We hypothesized that causal SNPs could play a significant role in severe malaria by altering promoter or enhancer activity. Here, we sought to identify such regulatory SNPs. METHODS: SNPs in linkage disequilibrium with tagSNPs associated with severe malaria...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-Ribosylation Factors
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Linkage Disequilibrium

Share to Malaria

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Share to Senegal

Source

Open in PubMed Open full text

Identifiers

PMID: 38531688
DOI: 10.1093/infdis/jiae159
PMCID: PMC11420786

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

From Genome-wide Association Studies to Functional Variants: ARL14 Cis-regulatory Variants Are Associated With Severe Malaria.PMID 38531688Read ↗

Functional analysis of genome-wide dataset from 17000 individuals identifies multiple candidate malaria resistance genes enriched in malaria pathogenic pathwaysSemantic proximity Read ↗

Identification of ATP2B4 Regulatory Element Containing Functional Genetic Variants Associated with Severe Malaria.Semantic proximity Read ↗

Unraveling a novel dual-function regulatory element showing epistatic interaction with a variant that escapes genome-wide association studiesSemantic proximity Read ↗

Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania.Semantic proximity Read ↗

Type I Interferon Receptor Variants in Gene Regulatory Regions are Associated with Susceptibility to Cerebral Malaria in Malawi.Semantic proximity Read ↗

Combined promoter haplotypes of the IL10R genes are associated with protection against severe malaria in Gabonese children.Semantic proximity Read ↗

TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression.Semantic proximity Read ↗

Genetics of Malaria Inflammatory Responses: A Pathogenesis PerspectiveSemantic proximity Read ↗

Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospectsSemantic proximity Read ↗

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study.Semantic proximity Read ↗

New insights into malaria susceptibility from the genomes of 17,000 individuals from Africa, Asia, and OceaniaSemantic proximity Read ↗

Population- and individual-specific regulatory variation in Sardinia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.