Article

Unraveling a novel dual-function regulatory element showing epistatic interaction with a variant that escapes genome-wide association studies

2024-03-19

Abstract excerpt

Regulation of gene expression has recently been complexified by the identification of Epromoters, a subset of promoters with enhancer function. Here, we uncovered the first dual cis-regulatory element, "ESpromoter," exhibiting both enhancer and silencer function, as a regulator of the nearby genes ATP2B4 and LAX1 in single human T cells. Through integrative approach, we pinpointed functional rs11240391, a severe...

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Literature Corpus work: 4d0867dc-81cd-5d6e-809a-1499a3d32086
DOI: 10.1101/2024.03.18.585566

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