Article
Combined promoter haplotypes of the IL10R genes are associated with protection against severe malaria in Gabonese children.
Immunogenetics - 1 Feb 2012
Velavan T P, Büyükyazici Birgül, Kremsner Peter G, Kun Jürgen F J
Abstract excerpt
The critical barrier in control of infections remains the failure of the immune system to clear parasites despite antigen recognition. We examined and validated possible association of regulatory immune gene polymorphisms in a cohort of children with mild and severe malaria. We focussed on two precursors of the Interleukin 10 Receptor (IL10R) gene namely the IL10R alpha and IL10R beta that play a fundamental role...
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