Article
Type I Interferon Receptor Variants in Gene Regulatory Regions are Associated with Susceptibility to Cerebral Malaria in Malawi.
The American journal of tropical medicine and hygiene - 1 Jun 2018
Feintuch Catherine Manix, Tare Archana, Cusumano Lucas R, Benayoun Jacqueline, Ryu Seungjin, Sixpence Alick, Seydel Karl, Laufer Miriam, Taylor Terrie, Suh Yousin, Daily Johanna P
Abstract excerpt
Cerebral malaria (CM) remains an important cause of morbidity and mortality. Risk for developing CM partially depends on host genetic factors, including variants encoded in the type I interferon (IFN) receptor 1 (IFNAR1). Type I IFNs bind to IFNAR1 resulting in increased expression of IFN responsive genes, which modulate innate and adaptive immune responses. To comprehensively study IFNAR1 genetic variant...
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