Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects

Abstract excerpt

BACKGROUND: P. falciparum malaria has been recognized as one of the prominent evolutionary selective forces of human genome that led to the emergence of multiple host protective alleles. A comprehensive understanding of the genetic bases of severe malaria susceptibility and resistance can potentially pave ways to the development of new therapeutics and vaccines. Genome-wide association studies (GWASs) have...

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