Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania.

Nature communications - 16 Dec 2019

Abstract excerpt

The human genetic factors that affect resistance to infectious disease are poorly understood. Here we report a genome-wide association study in 17,000 severe malaria cases and population controls from 11 countries, informed by sequencing of family trios and by direct typing of candidate loci in an additional 15,000 samples. We identify five replicable associations with genome-wide levels of evidence including a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Africa
Share to Asia
Share to Chromosomes, Human, Pair 6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Datasets as Topic

Share to Genetic Loci

Share to HLA Antigens

Share to Malaria, Falciparum

Share to Plasma Membrane Calcium-Transporting ATPases

Source

Open in PubMed Open full text

Identifiers

PMID: 31844061
DOI: 10.1038/s41467-019-13480-z
PMCID: PMC6914791

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania.PMID 31844061Read ↗

New insights into malaria susceptibility from the genomes of 17,000 individuals from Africa, Asia, and OceaniaSemantic proximity Read ↗

Genome-wide association study indicates two novel resistance loci for severe malaria.Semantic proximity Read ↗

Human genetics and malaria resistanceSemantic proximity Read ↗

Reappraisal of known malaria resistance loci in a large multicenter study.Semantic proximity Read ↗

Functional analysis of genome-wide dataset from 17000 individuals identifies multiple candidate malaria resistance genes enriched in malaria pathogenic pathwaysSemantic proximity Read ↗

Human genetic variations conferring resistance to malaria.Semantic proximity Read ↗

How malaria has affected the human genome and what human genetics can teach us about malaria.Semantic proximity Read ↗

Genome-Wide Association Studies of malaria susceptibility and resistance: progress, pitfalls and prospectsSemantic proximity Read ↗

African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children.Semantic proximity Read ↗

Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospectsSemantic proximity Read ↗

Genetic Variants That Confer Resistance to Malaria Are Associated with Red Blood Cell Traits in African-Americans: An Electronic Medical Record-based Genome-Wide Association StudySemantic proximity Read ↗

Genome-wide heritability analysis of severe malaria resistance reveals evidence of polygenic inheritance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.