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Article

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study.

The Lancet. Haematology - 1 Aug 2018

Ndila Carolyne M, Uyoga Sophie, Macharia Alexander W, Nyutu Gideon, Peshu Norbert, Ojal John, Shebe Mohammed, Awuondo Kennedy O, Mturi Neema, Tsofa Benjamin, Sepúlveda Nuno, Clark Taane G, Band Gavin, Clarke Geraldine, Rowlands Kate, Hubbart Christina, Jeffreys Anna, Kariuki Silvia, Marsh Kevin, Mackinnon Margaret, Maitland Kathryn, Kwiatkowski Dominic P, Rockett Kirk A, Williams Thomas N

Abstract excerpt

BACKGROUND: Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms-many related to the structure or function of red blood cells-and risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malaria, severe malaria anaemia, and respiratory distress. METHODS: We did a case-control study in Kilifi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30033078
DOI: 10.1016/S2352-3026(18)30107-8
PMCID: PMC6069675

Genes

FREM3
ABO
ADGRL2
ARL14
CAND1
GNAS
GYPA
GYPB
GYPE
HBA1
HBA2
HBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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