Article
TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression.
Malaria journal - 13 Mar 2009
Campino Susana, Forton Julian, Auburn Sarah, Fry Andrew, Diakite Mahamadou, Richardson Anna, Hull Jeremy, Jallow Muminatou, Sisay-Joof Fatou, Pinder Margaret, Molyneux Malcolm E, Taylor Terrie E, Rockett Kirk, Clark Taane G, Kwiatkowski Dominic P
Abstract excerpt
BACKGROUND: During malaria infection the Toll-like receptor 9 (TLR9) is activated through induction with plasmodium DNA or another malaria motif not yet identified. Although TLR9 activation by malaria parasites is well reported, the implication to the susceptibility to severe malaria is not clear. The aim of this study was to assess the contribution of genetic variation at TLR9 to severe malaria. METHODS: This...
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