A Functional Intronic Variant of LILRB1 Associated With Clinical Malaria in the Senegalese Population.

doi:10.1093/infdis/jiag007

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Article

A Functional Intronic Variant of LILRB1 Associated With Clinical Malaria in the Senegalese Population.

The Journal of infectious diseases - 2 Sept 2026

Dieppois Christelle, Chambonnier Gael, Gallardo Frederic, Torres Magali, Thiam Alassane, Mbengue Babacar, Dieye Alioune, Rihet Pascal, Paul Pascale

Abstract excerpt

BACKGROUND: Malaria remains a major health challenge in sub-Saharan Africa. Host genetic variation influences susceptibility, but the contribution of inhibitory receptors such as LILRB1-targeted by Plasmodium falciparum RIFINs-remains poorly defined. We investigated whether regulatory variants in LILRB1 modulate malaria risk. METHODS: Regulatory variants were prioritized from African expression quantitative trait...

Read the complete abstract on PubMed

Topics

Humans
Female
Malaria, Falciparum
Genetic Predisposition to Disease
Senegal
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Leukocyte Immunoglobulin-like Receptor B1

Male

Plasmodium falciparum

Introns

Quantitative Trait Loci

Linkage Disequilibrium

Adult

Genotype

Alleles

Child

Antigens, CD

Adolescent

Source

Open in PubMed

Identifiers

PMID: 41492925
DOI: 10.1093/infdis/jiag007

Genes

LILRB1
YY1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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