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Article

Identification of ATP2B4 Regulatory Element Containing Functional Genetic Variants Associated with Severe Malaria.

International journal of molecular sciences - 27 Apr 2022

Nisar Samia, Torres Magali, Thiam Alassane, Pouvelle Bruno, Rosier Florian, Gallardo Frederic, Ka Oumar, Mbengue Babacar, Diallo Rokhaya Ndiaye, Brosseau Laura, Spicuglia Salvatore, Dieye Alioune, Marquet Sandrine, Rihet Pascal

Abstract excerpt

Genome-wide association studies for severe malaria (SM) have identified 30 genetic variants mostly located in non-coding regions. Here, we aimed to identify potential causal genetic variants located in these loci and demonstrate their functional activity. We systematically investigated the regulatory effect of the SNPs in linkage disequilibrium (LD) with the malaria-associated genetic variants. Annotating and...

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Identifiers

PMID: 35563239
DOI: 10.3390/ijms23094849
PMCID: PMC9101746

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