Article

New insights into malaria susceptibility from the genomes of 17,000 individuals from Africa, Asia, and Oceania

2019-02-04

Abstract excerpt

We conducted a genome-wide association study of host resistance to severe Plasmodium falciparum malaria in over 17,000 individuals from 11 malaria-endemic countries, undertaking a wide ranging analysis which identifies five replicable associations with genome-wide levels of evidence. Our findings include a newly implicated variant on chromosome 6 associated with risk of cerebral malaria, and the discovery of an e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ff3e16d6-e8b2-5a5c-9af3-6fd8cbe17040
DOI: 10.1101/535898

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

New insights into malaria susceptibility from the genomes of 17,000 individuals from Africa, Asia, and OceaniaDOI 10.1101/535898Read

Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania.Semantic proximity Read

Genome-wide association study indicates two novel resistance loci for severe malaria.Semantic proximity Read

Human genetics and malaria resistanceSemantic proximity Read

How malaria has affected the human genome and what human genetics can teach us about malaria.Semantic proximity Read

Human genetic variations conferring resistance to malaria.Semantic proximity Read

Genome-Wide Association Studies of malaria susceptibility and resistance: progress, pitfalls and prospectsSemantic proximity Read

A novel locus of resistance to severe malaria in a region of ancient balancing selection.Semantic proximity Read

Genome-wide heritability analysis of severe malaria resistance reveals evidence of polygenic inheritance.Semantic proximity Read

Genetic polymorphisms linked to susceptibility to malaria.Semantic proximity Read

Reappraisal of known malaria resistance loci in a large multicenter study.Semantic proximity Read

Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospectsSemantic proximity Read

Functional analysis of genome-wide dataset from 17000 individuals identifies multiple candidate malaria resistance genes enriched in malaria pathogenic pathwaysSemantic proximity Read