Article
Model-Informed Precision Dosing of Isoniazid: Parametric Population Pharmacokinetics Model Repository.
Drug design, development and therapy - 1 Jan 2024
Ju Gehang, Liu Xin, Yang Wenyu, Xu Nuo, Chen Lulu, Zhang Chenchen, He Qingfeng, Zhu Xiao, Ouyang Dongsheng
Abstract excerpt
Introduction: Isoniazid (INH) is a crucial first-line anti tuberculosis (TB) drug used in adults and children. However, various factors can alter its pharmacokinetics (PK). This article aims to establish a population pharmacokinetic (popPK) models repository of INH to facilitate clinical use. Methods: A literature search was conducted until August 23, 2022, using PubMed, Embase, and Web of Science databases. We...
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