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Article

Population pharmacokinetics of isoniazid in adult Indian tuberculosis patients: Evaluation of NAT2 polymorphisms.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2026

Thomas Levin, Batcha Jaya Shree Dilli, Chaithra, Upadhyay Shubham, Parate Sakshi Sanjay, Prasad T S Keshava, Chidananda Sanju S V, Saravu Kavitha, Varma Muralidhar, Mallayasamy Surulivelrajan, Rao Mahadev

Abstract excerpt

INTRODUCTION: Gene polymorphisms in N-acetyltransferase 2 (NAT2) contribute to inter-individual variability in isoniazid pharmacokinetics among tuberculosis patients. India is a high tuberculosis-burden country and exhibits substantial genome diversity, which has important implications for precision medicine initiatives in tuberculosis. This study aimed to develop an isoniazid population pharmacokinetics (PopPK)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41570961
DOI: 10.1016/j.meegid.2026.105883

Genes

NAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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