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Article

Development of population pharmacokinetics model of isoniazid in Indonesian patients with tuberculosis.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Apr 2022

Soedarsono Soedarsono, Jayanti Rannissa Puspita, Mertaniasih Ni Made, Kusmiati Tutik, Permatasari Ariani, Indrawanto Dwi Wahyu, Charisma Anita Nur, Yuliwulandari Rika, Long Nguyen Phuoc, Choi Young-Kyung, Hoa Pham Quang, Hoa Pham Vinh, Cho Yong-Soon, Shin Jae-Gook

Abstract excerpt

OBJECTIVES: No population pharmacokinetics (PK) model of isoniazid (INH) has been reported for the Indonesian population with tuberculosis (TB). Therefore, we aimed to develop a population PK model to optimize pharmacotherapy of INH on the basis of therapeutic drug monitoring (TDM) implementation in Indonesian patients with TB. MATERIALS AND METHODS: INH concentrations, N-acetyltransferase 2 (NAT2) genotypes, and...

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PMID: 35017103
DOI: 10.1016/j.ijid.2022.01.003

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