Article
Influence of N-acetyltransferase 2 (NAT2) genotype/single nucleotide polymorphisms on clearance of isoniazid in tuberculosis patients: a systematic review of population pharmacokinetic models.
European journal of clinical pharmacology - 1 Oct 2022
Thomas Levin, Raju Arun Prasath, Chaithra, M Sonal Sekhar, Varma Muralidhar, Saravu Kavitha, Banerjee Mithu, Sv Chidananda Sanju, Mallayasamy Surulivelrajan, Rao Mahadev
Abstract excerpt
PURPOSE: Significant pharmacokinetic variabilities have been reported for isoniazid across various populations. We aimed to summarize population pharmacokinetic studies of isoniazid in tuberculosis (TB) patients with a specific focus on the influence of N-acetyltransferase 2 (NAT2) genotype/single-nucleotide polymorphism (SNP) on clearance of isoniazid. METHODS: A systematic search was conducted in PubMed and...
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