Article
Population Pharmacokinetic Analysis of Isoniazid among Pulmonary Tuberculosis Patients from China.
Antimicrobial agents and chemotherapy - 21 Feb 2020
Jing Wei, Zong Zhaojing, Tang Bohao, Wang Jing, Zhang Tingting, Wen Shu'an, Xue Yi, Chu Naihui, Zhao Wei, Huang Hairong
Abstract excerpt
The blood concentration of isoniazid (INH) is evidently affected by polymorphisms in N-acetyltransferase 2 (NAT2), an enzyme that is primarily responsible for the trimodal (i.e., fast, intermediate, and slow) INH elimination. The pharmacokinetic (PK) variability, driven largely by NAT2 activity, creates a challenge for the deployment of a uniform INH dosage in tuberculosis (TB) patients. Although...
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