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Article

Application of a physiologically based pharmacokinetic model to predict isoniazid disposition during pregnancy.

Clinical and translational science - 1 Nov 2023

Amaeze Ogochukwu U, Isoherranen Nina

Abstract excerpt

Pregnancy can increase the risk of latent tuberculosis infection (LTBI) progression to tuberculosis (TB) disease. Isoniazid (INH) is the preferred preventative treatment for LTBI in pregnancy. INH is mainly cleared by N-acetyltransferase 2 (NAT2) but the pharmacokinetics (PK) of INH in different NAT2 phenotypes during pregnancy is not well characterized. To address this knowledge gap, we used physiologically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37712488
DOI: 10.1111/cts.13614
PMCID: PMC10651660

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