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Article

Isoniazid Population Pharmacokinetics and Dose Recommendation for Korean Patients With Tuberculosis Based on Target Attainment Analysis.

Journal of clinical pharmacology - 1 Dec 2021

Cho Yong-Soon, Jang Tae Won, Kim Hyo-Jung, Oh Jee Youn, Lee Hyun-Kyung, Park Hye Kyeong, Ghim Jong-Lyul, Long Nguyen Phuoc, Park Yumi, Choi Young-Kyung, Phuong Nguyen Thi Thu, Shin Jae-Gook

Abstract excerpt

The wide variability of isoniazid (INH) pharmacokinetics is mainly attributed to the trimodal N-acetyltransferase 2 (NAT2) acetylator phenotype, that is, rapid, intermediate, and slow. Consequently, a uniform INH dose in current clinical practice may lead to treatment failure and emergence of drug resistance. There is a lack of studies on specific doses of INH for different NAT2 acetylator phenotypes among...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34157153
DOI: 10.1002/jcph.1931

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