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Article

Genetic and clinical predictors of rifapentine and isoniazid pharmacokinetics in paediatrics with tuberculosis infection.

The Journal of antimicrobial chemotherapy - 3 Jun 2024

Phaisal Weeraya, Albitar Orwa, Chariyavilaskul Pajaree, Jantarabenjakul Watsamon, Wacharachaisurapol Noppadol, Ghadzi Siti Maisharah Sheikh, Zainal Hadzliana, Harun Sabariah Noor

Abstract excerpt

OBJECTIVES: Twelve weekly doses of rifapentine and isoniazid (3HP regimen) are recommended for TB preventive therapy in children with TB infection. However, they present with variability in the pharmacokinetic profiles. The current study aimed to develop a pharmacokinetic model of rifapentine and isoniazid in 12 children with TB infection using NONMEM. METHODS: Ninety plasma and 41 urine samples were collected at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B

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Source

Identifiers

PMID: 38661209
DOI: 10.1093/jac/dkae059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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