Efficacy of isoniazid in paediatric tuberculosis: an individual participant data meta-analysis.

doi:10.1183/13993003.01046-2025

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Article

Efficacy of isoniazid in paediatric tuberculosis: an individual participant data meta-analysis.

The European respiratory journal - 1 Mar 2026

Béranger Agathe, Solans Belén P, Miyakawa Ryo, McIlleron Helen, Tarning Joel, Shah Ira, Aruldhas Blessed Winston, Mathew Binu Susan, Kwara Awewura, Peloquin Charles A, Mukherjee Aparna, Lodha Rakesh, Denti Paolo, Capparelli Edmund V, Kiser Jennifer J, Bekker Adrie, Chabala Chishala, Choo Louise, Turkova Anna, Gafar Fajri, Ruslami Rovina, Nataprawira Heda M, Heysell Scott K, Thomas Tania A, Velpandian Thirumurthy, Day Jeremy N, Bang Nguyen Duc, Dooley Kelly, Savic Radojka M

Abstract excerpt

BACKGROUND: Isoniazid is a cornerstone of management therapy for tuberculosis (TB). Our aim was to determine the association between isoniazid exposure and clinical outcomes, to develop a pharmacokinetic model, and to optimise the dosing regimen in children treated for drug-susceptible (DS)-TB. METHODS: For this individual participant data meta-analysis, PubMed was searched for observational studies, involving...

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PMID: 41412716
DOI: 10.1183/13993003.01046-2025

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NAT2

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