Fitness Effects of Phenotypic Mutations at Proteome-Scale Reveal Optimality of Translation Machinery.

doi:10.1093/molbev/msae048

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Article

Fitness Effects of Phenotypic Mutations at Proteome-Scale Reveal Optimality of Translation Machinery.

Molecular biology and evolution - 1 Mar 2024

Landerer Cedric, Poehls Jonas, Toth-Petroczy Agnes

Abstract excerpt

Errors in protein translation can lead to non-genetic, phenotypic mutations, including amino acid misincorporations. While phenotypic mutations can increase protein diversity, the systematic characterization of their proteome-wide frequencies and their evolutionary impact has been lacking. Here, we developed a mechanistic model of translation errors to investigate how selection acts on protein populations...

Topics

Proteome
Saccharomyces cerevisiae
Protein Biosynthesis
Escherichia coli
Amino Acids
RNA, Transfer
Codon
Mutation

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Identifiers

PMID: 38421032
DOI: 10.1093/molbev/msae048
PMCID: PMC10939442

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