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Article

Pairs of amino acids at the P- and A-sites of the ribosome predictably and causally modulate translation-elongation rates.

Journal of molecular biology - 4 Dec 2020

Ahmed Nabeel, Friedrich Ulrike A, Sormanni Pietro, Ciryam Prajwal, Altman Naomi S, Bukau Bernd, Kramer Günter, O'Brien Edward P

Abstract excerpt

Variation in translation-elongation kinetics along a transcript's coding sequence plays an important role in the maintenance of cellular protein homeostasis by regulating co-translational protein folding, localization, and maturation. Translation-elongation speed is influenced by molecular factors within mRNA and protein sequences. For example, the presence of proline in the ribosome's P- or A-site slows down...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptide Chain Elongation, Translational

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Source

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Identifiers

PMID: 33152326
DOI: 10.1016/j.jmb.2020.10.030
PMCID: PMC8270670

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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