Article
tRNA-modifying enzyme mutations induce codon-specific mistranslation and protein aggregation in yeast.
RNA biology - 1 Apr 2021
Tavares Joana F, Davis Nick K, Poim Ana, Reis Andreia, Kellner Stefanie, Sousa Inês, Soares Ana R, Moura Gabriela M R, Dedon Peter C, Santos Manuel
Abstract excerpt
Protein synthesis rate and accuracy are tightly controlled by the cell and are essential for proteome homoeostasis (proteostasis); however, the full picture of how mRNA translational factors maintain protein synthesis accuracy and co-translational protein folding are far from being fully understood. To address this question, we evaluated the role of 70 yeast tRNA-modifying enzyme genes on protein aggregation and...
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