Article
Genetic code ambiguity: an unexpected source of proteome innovation and phenotypic diversity.
Current opinion in microbiology - 1 Dec 2009
Moura Gabriela R, Carreto Laura C, Santos Manuel A S
Abstract excerpt
Translation of the genome into the proteome is a highly accurate biological process. However, the molecular mechanisms involved in protein synthesis are not error free and downstream protein quality control systems are needed to counteract the negative effects of translational errors (mistranslation) on proteome and cell homeostasis. This plus human and mice diseases caused by translational error generalized the...
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